Powerful Combination of Bacopa Monnieri, Lion’s Mane, and Ginkgo Biloba

Science Behind Namobrain IgniteThis is a guest post by the guys over at Namobrain. The biotechnology company has just released it first product called Ignite(Namobrain Ignite). It’s a all natural cognitive enhancer that boosts long-term memory, improves mood, motivation and focus. YES, did I say it’s all-natural. Namobrain will now explain the science behind Ignite:

Science Behind Namobrain Ignite – A Natural Nootropic

Do natural nootropics work? What is the most powerful and effective all natural nootropic stack? This is one of the most common questions asked by individuals introduced to the world of natural cognitive enhancement. Naturally, the scientific community interested in the smart drug world grew over the past decade reflecting increasing scientific research in this field.

The team at Namobrain dug deep into the scientific community and its research to create IGNITE, an all natural unique nootropic composed of the right dosage of Bacopa Monnieri, Lion’s Mane mushroom, and Ginkgo Biloba. Here is what research is saying about these ingredients.

Bacopa Monnieri

Bacopa Monnieri

Bacopa Monnieri

Starting with Bacopa, any google search will show you articles and scientific journals discussing its memory boosting ability. Bacopa Monnieri is perhaps one of the most scientifically studied compounds when it comes to nootropics. In 2008, The Journal of Alternative and Complementary Medicine published a paper titled Effects of a Standardized Bacopa Monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial. The study was performed by scientists in the Department of Neurology of the Oregon Health & Science University (Portland, OR).

The study’s aim was to evaluate effects of Bacopa Monnieri whole plant standardized dry extract on cognitive function as well as its safety and tolerability in healthy elderly study participants. The study involved 48 partipants, 65 years old or older, without clinical signs of dementia, half of them taking Bacopa monnieri while the other half taking placebo pills. Controlling for baseline cognitive deficit using the Blesse Orientationâl Memoryâ Concentration test, Bacopa participants had enhanced AVLT delayed word recall memory scores relative to placebo.

Stroop results were similarly significant, with the Bacopa group improving and the placebo group unchanged. CESD-10 depression scores, combined state plus trait anxiety scores, and heart rate decreased over time for the Bacopa group but increased for the placebo group. No effects were found on the DAT, WAIS digit task, mood, or blood pressure. The dose was well tolerated with few adverse events (Bacopa n = 9, placebo n = 10), primarily stomach upset. The study provides further evidence that Bacopa Monnieri has potential for safely enhancing cognitive performance.

Other studies came to a similar conclusion, notably the Meta-analysis of randomized controlled trials on cognitive effects of Bacopa Monnieri extract which concluded that Bacopa Monnieri extract may be beneficial in improving cognitive function in the attention domain, especially speed of attention. Nevertheless, there is a clear and urgent need for large scale independent clinical trials on well characterized patient cohorts, using rigorously applied design criteria and well established end-points. We hope to partner with a research centre to start a large scale study on the subject.

Lion’s Mane Mushroom

Lion’s Mane Mushroom

Lion’s Mane Mushroom

On the Namobrain website, Lion’s Mane Mushroom is described as nature’s nutrient for your neurons as it stimulates the synthesis of Nerve Growth Factor (NGF), a secreted protein that plays a key role in neurogenesis, the process by which the human brain grows new neurons. Known in the scientific community as Hericium erinaceus, Lion’s Mane mushroom contains neuroactive compounds which induce NGF-synthesis and promote neurite outgrowth of the neuroblastoma-glioma cell NG108-15.

The influence of lion’s mane on neurological functions may also have other added benefits — making you feel good. In another small clinical study (n=30), postmenopausal women who consumed lion’s mane baked into cookies vs. those without showed less anxiety and depression while showing an improvement in their ability to concentrate (Nagano et al., 2010).

In light of the numerous diseases related to neurodegeneration, lion’s mane deserves more clinical attention. Lion’s mane may be our first “smart” mushroom. It is a safe, edible fungus that appears to confer cognitive benefits on our aging population. Unfortunately, lion’s mane is not available in most grocery stores. That’s one more thing we hope to change with IGNITE.

Ginkgo Biloba

Ginkgo Biloba

Ginkgo Biloba

Last but not least, we have Ginkgo Biloba, the world’s best-selling cognitive enhancer used to treat blood disorders and memory loss by increasing the blood flow to the brain, opening up blood vessels and making blood less sticky. Some men use the plant for sexual enhancement supplements as the improved blood flow helps with sexual arousal. We use it for cognitive enhancement as the increase of blood flow in the brain fuels it for peak cognitive performance.

The focus in clinical studies is on the effectiveness of standardized ginkgo biloba liquid extract made from the plant’s dried green leaves. According to Traditional Chinese Medicine and current clinical studies, ginkgo biloba is safe, effective and benefits the body in numerous ways because it exerts protective effects against mitochondrial damage and oxidative stress. It’s been used in Chinese herbal medicine to treat a variety of medical conditions since ancient times, especially circulatory problems and those related to declining memory. Ginkgo biloba extract contains two constituents (flavonoids and terpenoids) that have strong antioxidant properties.

It’s believed these may help slow down the progression of age-related diseases by combating oxidative stress that usually worsens as someone ages.  Laboratory and animal studies show that flavonoids protect the nerves, heart muscles, blood vessels, and retina from damage. Terpenoids (such as ginkgolides) improve blood flow by dilating blood vessels and reducing the stickiness of platelets. Since it can help increase uptake of glucose (broken down sugar) by brain cells, it has the potential to improve the transmission of nerve signals responsible for memory, mood, task completion, heartbeat regulation and eye health — in addition to many other vital functions.


As you can see, the current studies are positive but we need more large scale studies before calling nootropics smart pills. What those studies show is that the compounds have neurological benefits and can be safely used to treat dementia and boost cognitive functions. We all react differently to what we put into our bodies so doing your own research and experimenting is key to finding out what works for you. For some people, a couple of shots of espresso will do, for some IGNITE is a must. We invite you to contact our team via email (info@namobrain.com) or via twitter @namobrain to share your experiences, fears and questions. The journey to enhance intelligence is the most noble journey there is, human intelligence creates the machine that create the future. Let’s enhance our mind together, one study at a time.

Photo Credit:Lion’s Mane Mushroom, By Rob Hille (Own work) [CC BY-SA 3.0], via Wikimedia Commons

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